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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL3
All Species:
40.91
Human Site:
S221
Identified Species:
60
UniProt:
Q13618
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13618
NP_003581.1
768
88930
S221
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Chimpanzee
Pan troglodytes
XP_001167451
757
87889
S210
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Rhesus Macaque
Macaca mulatta
XP_001109600
746
86448
S199
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Dog
Lupus familis
XP_534586
746
86477
S199
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLV5
768
88930
S221
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Rat
Rattus norvegicus
Q9JJ31
780
90872
A218
E
R
F
Y
R
T
Q
A
P
S
Y
L
Q
Q
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512511
642
74121
V122
I
N
E
E
I
E
R
V
M
H
C
L
D
K
S
Chicken
Gallus gallus
XP_422620
768
88957
S221
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Frog
Xenopus laevis
Q6DE95
768
88933
S221
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Zebra Danio
Brachydanio rerio
NP_955985
766
89011
S219
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
S239
S
A
F
Y
E
K
E
S
D
A
F
L
S
T
N
Honey Bee
Apis mellifera
XP_625079
767
89385
S218
A
E
F
Y
R
M
E
S
Q
K
F
L
A
E
N
Nematode Worm
Caenorhab. elegans
Q17391
777
90217
C219
S
D
Y
Y
R
D
V
C
K
N
W
L
S
G
D
Sea Urchin
Strong. purpuratus
XP_001178314
675
78472
E155
K
V
E
A
R
I
N
E
E
A
E
R
A
V
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
A208
S
S
Y
Y
S
R
K
A
S
S
W
I
Q
E
D
Baker's Yeast
Sacchar. cerevisiae
P53202
744
86097
T207
E
P
V
L
I
S
A
T
E
E
Y
Y
N
K
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.1
96.8
N.A.
99.4
26.4
N.A.
83.1
99.6
98.5
95.9
N.A.
28.4
77.2
49.6
67
Protein Similarity:
100
98
97.1
96.8
N.A.
99.6
49.4
N.A.
83.3
99.7
99.2
98.3
N.A.
52.4
87.5
69.1
76.9
P-Site Identity:
100
100
100
100
N.A.
100
20
N.A.
6.6
100
100
100
N.A.
40
86.6
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
60
N.A.
20
100
100
100
N.A.
66.6
100
66.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.3
26.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.5
46.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
57
7
0
7
0
0
7
13
0
13
0
0
63
0
7
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% C
% Asp:
0
7
0
0
0
7
0
0
7
0
0
0
7
0
13
% D
% Glu:
13
57
13
7
7
7
63
7
13
7
7
0
0
63
0
% E
% Phe:
0
0
69
50
0
0
0
0
0
0
63
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% H
% Ile:
7
0
0
0
13
7
0
0
0
0
0
7
0
0
0
% I
% Lys:
7
0
0
0
0
7
7
0
7
57
0
0
0
13
0
% K
% Leu:
0
0
0
7
0
0
0
0
0
0
0
82
0
0
0
% L
% Met:
0
0
0
0
0
57
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
7
0
0
7
0
0
7
0
69
% N
% Pro:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
50
0
7
0
57
0
0
0
13
7
0
% Q
% Arg:
0
7
0
0
25
7
7
0
0
0
0
7
0
0
0
% R
% Ser:
19
7
0
0
7
7
0
63
7
13
0
0
13
0
7
% S
% Thr:
0
0
0
0
0
7
0
7
0
0
0
0
0
7
0
% T
% Val:
0
7
7
0
0
0
7
7
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% W
% Tyr:
0
0
13
32
0
0
0
0
0
0
13
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _